Franz Jakob Selected Research

N- (4'- fluorobutyrophenone)- 4- (4- chlorophenyl)pyridinium (HPP(+))

5/2021	[Rare bone disorders and respective treatments].
1/2021	TNAP as a New Player in Chronic Inflammatory Conditions and Metabolism.
12/2020	Tissue-Nonspecific Alkaline Phosphatase-A Gatekeeper of Physiological Conditions in Health and a Modulator of Biological Environments in Disease.
1/2020	Pediatric hypophosphatasia: lessons learned from a retrospective single-center chart review of 50 children.
1/2020	Novel molecular cues for dental defects in hypophosphatasia.
1/2020	Investigation of alpl expression and Tnap-activity in zebrafish implies conserved functions during skeletal and neuronal development.
6/2017	Efficacy of anti-sclerostin monoclonal antibody BPS804 in adult patients with hypophosphatasia.
1/2017	A homozygous intronic branch-point deletion in the ALPL gene causes infantile hypophosphatasia.
10/2015	Overexpression of tissue-nonspecific alkaline phosphatase increases the expression of neurogenic differentiation markers in the human SH-SY5Y neuroblastoma cell line.
1/2015	Recombinant Enzyme Replacement Therapy in Hypophosphatasia.

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Franz Jakob Research Topics

Disease

23	Osteoporosis 01/2022 - 01/2007
21	Neoplasms (Cancer) 12/2022 - 05/2003
13	Hypophosphatasia 01/2022 - 10/2014
6	Neoplasm Metastasis (Metastasis) 12/2022 - 01/2010
6	Breast Neoplasms (Breast Cancer) 11/2021 - 01/2010
6	Bone Resorption 09/2019 - 01/2002
5	Osteolysis 01/2022 - 06/2004
5	Prostatic Neoplasms (Prostate Cancer) 11/2021 - 06/2011
3	Pain (Aches) 01/2022 - 02/2008
3	Rare Diseases (Rare Disease) 01/2022 - 01/2020
3	Inflammation (Inflammations) 01/2021 - 11/2005
3	Postmenopausal Osteoporosis 11/2020 - 05/2012
3	Inborn Genetic Diseases (Disease, Hereditary) 01/2020 - 10/2015
3	Metabolic Bone Diseases (Osteopenia) 01/2020 - 03/2012
3	Bone Diseases (Bone Disease) 01/2016 - 06/2014
3	Back Pain (Backache) 05/2012 - 12/2009
3	Carcinogenesis 03/2012 - 01/2003
2	Multiple Myeloma 12/2022 - 01/2016
2	Osteogenesis Imperfecta (Lobstein Disease) 01/2022 - 07/2017
2	Metabolic Diseases (Metabolic Disease) 12/2020 - 01/2014
2	Sarcopenia 08/2020 - 01/2020
2	Vitamin D Deficiency 11/2019 - 09/2017
2	Rickets (Rachitis) 04/2016 - 03/2006
2	Congenital Abnormalities (Deformity) 04/2016 - 02/2008
2	Infections 08/2010 - 03/2007
2	Colonic Neoplasms (Colon Cancer) 01/2004 - 01/2003
1	Edema (Dropsy) 01/2022
1	Hypophosphatemia 05/2021
1	Secondary Hyperparathyroidism 11/2019
1	Juvenile Arthritis (Juvenile Idiopathic Arthritis) 09/2019
1	Anterior Cruciate Ligament Injuries 09/2018
1	Myositis (Idiopathic Inflammatory Myopathies) 01/2017
1	Neuroblastoma 10/2015
1	Seizures (Absence Seizure) 10/2015
1	Rotator Cuff Injuries 06/2015

Drug/Important Bio-Agent (IBA)

11	N- (4'- fluorobutyrophenone)- 4- (4- chlorophenyl)pyridinium (HPP(+))IBA 05/2021 - 10/2014
10	Diphosphonates (Bisphosphonates)IBA 01/2022 - 02/2008
8	Alkaline PhosphataseIBA 05/2021 - 07/2012
6	Vitamin D FDA LinkGeneric 01/2022 - 03/2006
6	Zoledronic Acid (Zometa)FDA Link 01/2022 - 01/2010
5	Proteins (Proteins, Gene)FDA Link 11/2021 - 09/2002
5	Teriparatide (Parathar)FDA Link 08/2013 - 02/2008
4	CytokinesIBA 01/2022 - 12/2006
4	EnzymesIBA 01/2021 - 05/2003
3	CalciumIBA 01/2020 - 04/2016
3	Biomarkers (Surrogate Marker)IBA 01/2018 - 01/2016
3	Messenger RNA (mRNA)IBA 01/2012 - 06/2003
3	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 04/2007 - 11/2005
3	SeleniumIBA 01/2004 - 09/2002
3	Glutathione PeroxidaseIBA 01/2004 - 01/2003
2	Phosphates (Orthophosphate)IBA 05/2021 - 02/2014
2	Estrogen ReceptorsIBA 11/2020 - 01/2010
2	Estrogens (Estrogen)FDA Link 11/2020 - 01/2014
2	CateninsIBA 11/2020 - 07/2015
2	Parathyroid Hormone (Parathormone)IBA 11/2019 - 06/2017
2	setrusumabIBA 07/2017 - 06/2017
2	MineralsIBA 05/2016 - 10/2014
2	diphosphoric acid (pyrophosphoric acid)IBA 12/2014 - 03/2012
2	Gonadal Steroid Hormones (Sex Hormones)IBA 06/2014 - 06/2013
2	Mevalonic Acid (Mevalonate)IBA 02/2014 - 03/2012
2	Hormones (Hormone)IBA 01/2014 - 01/2007
2	Intercellular Signaling Peptides and Proteins (Growth Factors)IBA 07/2012 - 02/2012
2	Cholecalciferol (Vitamin D3)FDA Link 01/2012 - 03/2006
2	Transcription Factors (Transcription Factor)IBA 08/2010 - 04/2007
2	Reactive Oxygen Species (Oxygen Radicals)IBA 05/2006 - 01/2004
2	Selenoproteins (Selenoprotein)IBA 01/2004 - 01/2002
2	Selenoprotein PIBA 01/2004 - 09/2002
1	Junctional Adhesion Molecule CIBA 12/2022
1	Immunoglobulins (Immunoglobulin)IBA 12/2022
1	romosozumabIBA 01/2022
1	alpha2 Subunit Collagen Type IIBA 01/2022
1	NanodiamondsIBA 11/2021
1	Pharmaceutical PreparationsIBA 01/2021
1	LigandsIBA 11/2020
1	Whey ProteinsIBA 08/2020
1	RNA (Ribonucleic Acid)IBA 01/2020
1	Levamisole (Decaris)FDA Link 01/2020
1	Wnt ReceptorsIBA 06/2018
1	Granulocyte Colony-Stimulating Factor (G-CSF)IBA 01/2018
1	hydroxide ionIBA 09/2017
1	collagen type I trimeric cross-linked peptideIBA 06/2017
1	Procollagen Type IIBA 06/2017
1	Monoclonal AntibodiesIBA 06/2017
1	Collagen Type I (Type I Collagen)IBA 06/2017
1	OsteocalcinIBA 06/2017
1	Matrix Metalloproteinases (MMPs)IBA 01/2017
1	MyostatinIBA 01/2017
1	Kisspeptin-1 ReceptorsIBA 01/2016
1	Microtubule-Associated Proteins (Microtubule-Associated Protein 2)IBA 10/2015
1	RNA-Binding Proteins (RNA-Binding Protein)IBA 10/2015
1	Carrier Proteins (Binding Protein)IBA 10/2015
1	Phosphopyruvate Hydratase (Enolase)IBA 10/2015
1	Differentiation AntigensIBA 10/2015
1	Heparin (Liquaemin)FDA LinkGeneric 09/2015
1	Collagenases (Collagenase)FDA Link 06/2015

Therapy/Procedure

8	Therapeutics 01/2021 - 02/2008
2	Arthroplasty 03/2007 - 06/2004
1	Aftercare (After-Treatment) 01/2022
1	Resistance Training 01/2020
1	Osteotomy 04/2016